|
KMID : 1130620160120020172
|
|
Journal of Clinical Neurology
2016 Volume.12 No. 2 p.172 ~ p.180
|
|
|
Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to α-Synuclein Oligomer
|
|
Li-Jun Zuo
Shu-Yang Yu
Fang Wang
Yang Hu
Ying-Shan Piao
Yang Du
Teng-Hong Lian
Rui-Dan Wang
Qiu-Jin Yu
Ya-Jie Wang
Xiao-Min Wang
Piu Chan
Sheng-Di Chen
Yong-Jun Wang
Wei Zhang
|
|
|
Abstract
|
|
|
Background and Purpose : The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson's disease (PD) patients who experience fatigue.
Methods : PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins?α-synuclein oligomer, β-amyloid (Aβ)1-42, and tau?were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients.
Results : The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of α-synuclein oligomer was higher and that of Aβ1-42 was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the α-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders.
Conclusions : PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased α-synuclein oligomer level in the CSF.
|
|
|
KEYWORD
|
|
|
Parkinson's disease, fatigue, motor symptoms, nonmotor symptoms, α-synuclein oligomer, cerebrospinal fluid
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|